Table 3.
The results of subgroup analysis.
| Covariates | No. studies | Sen (95%CI) | Spe (95%CI) | PLR (95%CI) | NLR (95%CI) | DOR (95%CI) | AUC (95%CI) |
|---|---|---|---|---|---|---|---|
| Sample source | |||||||
| Plasma | 8 | 0.80 (0.63–0.90) | 0.81 (0.72–0.87) | 4.1 (2.9–5.9) | 0.25 (0.14–0.47) | 16 (7–36) | 0.86 (0.83–0.89) |
| Serum | 16 | 0.86 (0.83–0.88) | 0.86 (0.81–0.90) | 6.0 (4.4–8.3) | 0.17 (0.14–0.20) | 36 (24–54) | 0.91 (0.88–0.93) |
| Dysregulated miRNAs | |||||||
| Up | 13 | 0.82 (0.73–0.89) | 0.84 (0.77–0.90) | 5.3 (3.6–7.8) | 0.21 (0.14–0.33) | 25 (13–47) | 0.90 (0.87–0.93) |
| Down | 11 | 0.85 (0.83–0.87) | 0.84 (0.78–0.88) | 5.3 (3.9–7.2) | 0.17 (0.15–0.21) | 30 (20–46) | 0.88 (0.85–0.90) |
| Internal reference | |||||||
| U6 | 15 | 0.80 (0.74–0.86) | 0.83 (0.77–0.88) | 4.8 (3.5–6.7) | 0.24 (0.18–0.31) | 20 (13–32) | 0.89 (0.86–0.91) |
| Non–U6 | 7 | 0.86 (0.83–0.88) | 0.83 (0.77–0.88) | 5.1 (3.7–7.1) | 0.17 (0.14–0.21) | 30 (19– 47) | 0.88 (0.85–0.91) |
| NA | 2 | 0.96 (0.91–0.98) | 0.90 (0.85–0.94) | 9.6 (3.2–29) | 0.05 (0.01–0.17) | 262 (95–724) | NAa |
| Comparison type | |||||||
| Gliomas vs. HC | 21 | 0.84 (0.78–0.88) | 0.83 (0.78–0.87) | 4.8 (3.8–6.1) | 0.20 (0.15–0.26) | 24 (16–36) | 0.90 (0.87–0.92) |
| HGG vs. HC | 2 | 0.80 (0.74–0.86) | 0.89 (0.83–0.94) | 7.1 (1.9–26.5) | 0.24 (0.17–0.35) | 30 (12–74) | NAa |
| Astrocytomas vs. HC | 1 | 0.933 | 0.945 | – | – | – | 0.97 (0.95–0.99) |
| miRNA profiling | |||||||
| Single miRNA | 21 | 0.83 (0.78–0.87) | 0.82 (0.78–0.86) | 4.7 (3.8–5.8) | 0.20 (0.16–0.26) | 23 (16–32) | 0.89 (0.86–0.92) |
| miRNA panel | 3 | 0.87 (0.82–0.91) | 0.94 (0.90 −0.96) | 13 (3.7–45.5) | 0.15 (0.06–0.36) | 96 (12–741) | NAa |
| Sample size | |||||||
| ≥100 | 19 | 0.86 (0.81–0.89) | 0.86 (0.81–0.89) | 5.9 (4.6–7.7) | 0.17 (0.13–0.22) | 35 (23–53) | 0.92 (0.90–0.94) |
| <100 | 5 | 0.73 (0.58–0.84) | 0.77 (0.61–0.88) | 3.2 (2.0–5.0) | 0.36 (0.25–0.51) | 9 (6–14) | 0.81 (0.78–0.84) |
| Cut-off values | |||||||
| Given | 18 | 0.82 (0.77–0.87) | 0.84 (0.79–0.88) | 5.2 (3.8–7.0) | 0.21 (0.16–0.28) | 25 (15–40) | 0.90 (0.87–0.92) |
| NA | 6 | 0.87 (0.79–0.93) | 0.85 (0.75–0.91) | 5.6 (3.5–9.2) | 0.15 (0.09–0.25) | 37 (19–73) | 0.92 (0.90–0.94) |
a
The number of studies was too small to fit the curve.
Sen, sensitivity; Spe, specificity; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; AUC, area under the curve; NA, not available; CI, confidence interval.