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. 2021 Feb 1;7:630480. doi: 10.3389/fcvm.2020.630480

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Copyright © 2021 McMullen, Chalmers, Wood, Cunningham and Currie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sunitinib treatment increases ox-CaMKII expression in cardiac fibroblasts. Following the indicated treatments with either sunitinib or imatinib, CaMKIIδ expression or CaMKII activation via phosphorylation or oxidation was determined via quantitative immunoblotting (A) CaMKIIδ expression, normalized to GAPDH (B) Phos-CaMKII expression, normalized to CaMKIIδ (C) Ox-CaMKII expression, normalized to CaMKIIδ (D) Representative immunoblot showing CaMKIIδ expression and CaMKII activation following TKI treatment. Results are expressed as mean ratios protein: GAPDH ± S.E.M and are normalized to control (n = 3, *p < 0.05).