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. 2021 Feb 1;7:630480. doi: 10.3389/fcvm.2020.630480

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Copyright © 2021 McMullen, Chalmers, Wood, Cunningham and Currie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sunitinib and imatinib treatments both cause increased mitochondrial superoxide production in cardiac fibroblasts. (Ai) Histogram showing superoxide production assessed via fluorescence intensity in antimycin A and vehicle treated CFs (Aii) Representative images of MitoSOX Red analysis of antimycin A and vehicle treated samples. (Bi) Superoxide production assessed via fluorescence intensity in sunitinib treated CFs (Bii) Representative images of MitoSOX Red analysis of sunitinib treated samples. (Ci) Superoxide production assessed via fluorescence intensity in imatinib treated CFs (Cii) Representative images of MitoSOX Red analysis of imatinib treated samples. Scale bar 100 μm. Results shown are mean data from one experiment (n = 10), representative of two other experiments (*p < 0.05).