TABLE 2.
Overview of referrals to studies
| Design | Study description | Invited | Responded | Interested | Enrolled |
|---|---|---|---|---|---|
| Online (n=9) | Survey on knowledge and attitudes toward dementia risk reduction in CN (Lifestyle) | 10,276 | 4388 | 3466 | 3466 |
| Online test battery on daily functioning and cognition in cognitively normal population (Think&Do) | 8380 | 8359 | 4386 | 3204 | |
| Effect of age and sex on navigation skills (Navigation) | 5839 | 2665 | 2159 | 2159 | |
| Screening for music‐based intervention (Music) | 2613 | 1344 | 1002 | 1002 | |
| Validity of online social behavior application in CN, SCD, and AD (BeHapp) | 2828 | 1479 | 443 | 317 | |
| Information provision regarding diagnostic testing in AD patient caregivers (ABIDE‐Delphi) 15 | 977 | 617 | 141 | 31 | |
| RCT on best‐practice advice for PET disclosure (ABIDE Simulation) | 701 | 319 | 231 | 231 | |
| Study on feasibility of application‐based lifestyle intervention strategy in SCD (Euro‐SCD) | 77 | 64 | 48 | 36 | |
| Study on validity of application‐based lifestyle intervention strategy in SCD (HelloBrain) | 135 | 82 | 63 | 55 | |
| Subtotal | 31,826 | 19,317 (61%) | 11,939 (38%) | 10,501 (33%) | |
| Site visit, observational (n=14) | Multicenter, pan‐European, longitudinal cohort study in adults without dementia (EPAD) 16 | 663 | 405 | 234 | 104 |
| Multicenter, pan‐European study on patient engagement strategies in non‐demented elderly (MOPEAD) 17 | 362 | 225 | 145 | 107 | |
| Study on predictors of music‐cued precision in CN (Moving to music) | 248 | 91 | 51 | 33 | |
| Study on cognitive correlates of connectivity in CN (MuMoBrain) | 213 | 90 | 36 | 17 | |
| Study on movement and cognition in CN (MIB) | 212 | 108 | 45 | 19 | |
| Multicenter study on the biological construct of social withdrawal in AD and schizophrenia (PRISM) 18 | 188 | 86 | 21 | 10 | |
| Longitudinal cohort study in adults with SCD (SCIENCE) 19 | 153 | 92 | 46 | 31 | |
| Study on insomnia and affect in isomnia patients and CN (Sleep) | 111 | 48 | 9 | 1 | |
| Study on brain networks and tau pathology in CN, SCD, MCI, and AD (MANTA) | 44 | 15 | 13 | 6 | |
| MRI study in OCD patients and CN (OCD) | 20 | 6 | 5 | 3 | |
| Study on development of a cognitive measure for progression in SCD, MCI, and dementia (CatchCog) 20 | 19 | 13 | 8 | 0 | |
| Remote Assessment of Disease and Relapse in MDD (RADAR‐CNS) 21 | 15 | 8 | 5 | 1 | |
| Effect of light on emotional processing in PD, MDD, and CN (Light) | 11 | 6 | 6 | 0 | |
| Study on resilience to dementia in elderly aged ≥90 (EMIF AD 90+) 22 | 10 | 6 | 5 | 1 | |
| Subtotal | 2269 | 1199 (53%) | 583 (26%) | 333 (15%) | |
| Intervention (n=5) | RCT of exercise intervention in vascular cognitive disorders (Excersion‐VCI) 23 | 170 | 98 | 46 | 18 |
| RCT of treatment in anxiety‐ or MDD patients (MOTAR) 24 | 167 | 96 | 15 | 8 | |
| Study on effectiveness navigation rehabilitation training in people with acquired brain injury and CN (Wayfinder) | 156 | 90 | 24 | 3 | |
| RCT of exercise intervention in CN (Move) | 91 | 62 | 35 | 26 | |
| RCT of cognitive training in PD (Cogtips) 25 | 17 | 14 | 10 | 3 | |
| Subtotal | 601 | 360 (60%) | 115 (19%) | 58 (10%) | |
| Total | 34696 | 20876 (60%) | 12637 (36%) | 10661 (31%) |
Note: Data are presented as n or n (%).
Abbreviations: AD, Alzheimer's disease; CN, cognitively normal adults; MCI, mild cognitive impairment; MDD; major depression disorder; PD, Parkinson's disease; SCD, subjective cognitive decline; RCT, randomized controlled trial.