. 2021 Feb 14;7(1):e12119. doi: 10.1002/trc2.12119

TABLE 2.

Cox proportional hazard regression models with associations between dementia incidence and herpes infection with and without antiviral treatment compared to controls without antiviral treatment or herpes diagnosis

Unadjusted hazard ratio, 95% confidence interval, (P value)	Adjusted hazard ratio, 95% confidence interval, (P value)
Herpes diagnosis, no antiviral treatment, compared to controls
1.43, 1.24–1.65 (<.001)	1.50, 1.29–1.74 (<.001) ^a
Herpes diagnosis, with antiviral treatment, compared to controls
0.91, 0.83–0.98, (.02)	0.90, 0.82–0.98 (.015) ^a
Antiviral treatment, irrespective of diagnosis, compared to controls
0.89, 0.86–0.92 (<.001)	0.89, 0.86–0.92 (<.001) ^a
Herpes diagnosis, with antiviral treatment compared to those without antiviral treatment ^b
0.66, 0.60–0.73 (<.001)	0.75, 0.68–0.83 (<.001) ^c

^{^a}

Hazard ratios adjusted for baseline comorbidity (alcohol intoxication; chronic obstructive pulmonary disease; congestive heart failure; myocardial infarction; Parkinson's disease; stroke; and the use of antidepressant, antidiabetic, antihypertensive, and antipsychotics drugs) and educational level.

^{^b}

The comparison groups in this model are not matched by sex and age.

^{^c}

Hazard ratios adjusted for sex, age, baseline comorbidity (alcohol intoxication; chronic obstructive pulmonary disease; congestive heart failure; myocardial infarction; Parkinson's disease; stroke; and the use of antidepressant, antidiabetic, antihypertensive, and antipsychotics drugs) and educational level. For this analysis, sex and age were also included in the model because the comparison groups were not matched.