TABLE 2.
Region of interest results: difference (24 weeks minus baseline) mean, S.D. and difference between arms with 95% confidence interval
| Middle frontal | Anterior cingulate | Superior frontal | Striatum | Medial temporal | Lateral temporal | Post cing ‐ precuneus | Inferior parietal | |
|---|---|---|---|---|---|---|---|---|
| SUVRs | ||||||||
| Placebo | −0.032 (0.030) | −0.020 (0.021) | −0.016 (0.022) | −0.024 (0.029) | −0.015 (0.034) | −0.020 (0.029) | −0.017 (0.023) | −0.025 (0.029) |
| Rasagiline | −0.011 (0.030) | −0.003 (0.026) | −0.003 (0.018) | −0.002 (0.028) | −0.010 (0.034) | −0.016 (0.024) | −0.016 (0.018) | −0.018 (0.022) |
| Difference (95% CI) | 0.020 (0.00–0.04) | 0.016 (−0.00–0.03) | 0.013 (0.00–0.04) | 0.022 (0.00–0.04) | 0.005 (−0.02–0.03) | 0.005 (−0.01–0.02) | −0.001 (−0.01–0.01) | 0.007 (−0.01–0.02) |
| Percentages | ||||||||
| Placebo | −3.5% | −2.8% | −2.0% | −2.6% | −2.5% | −2.7% | −2.2% | −2.6% |
| (3.5%) | (3.1%) | (2.7%) | (3.1%) | (5.7%) | (4.4%) | (3.1%) | (3.5%) | |
| Rasagiline | −1.0% | −0.6% | −0.4% | −0.2% | −1.8% | −2.1% | −2.0% | −1.6% |
| (3.5%) | (3.1%) | (2.1%) | (3.1%) | (5.7%) | (4.4%) | (3.1%) | (3.5%) | |
| Difference (95% CI) | 2.5% (0.3‐4.7%) | 2.2% (0.1‐4.3%) | 1.6% (0.0‐3.2%) | 2.4% (0.2‐4.3%) | 0.8% (−2.4‐4.0%) | 0.6% (−1.8–3.0%) | 0.2% (−1.5–1.9%) | 0.9% (−1.5–3.3%) |
| P‐values a | 0.025 | 0.041 | 0.054 | 0.023 | n.s. | n.s. | n.s. | n.s. |
a
based on the SUVR values and comparison of differences from baseline. Abbreviation: ns, not significant.