FIGURE 3.

Annualized LS mean change from baseline in FDG PET SUVr from AMARANTH (A) and DAYBREAK‐ALZ (B) studies.

No significant differences in cerebral metabolism were observed between either of the lanabecestat groups and placebo. The standard errors for LS mean change in FDG SUVr in placebo, lanabecestat 20 mg, and lanabecestat 50 mg groups from AMARANTH study were < 0.01. Abbreviations: FDG, fluorodeoxyglucose; LS, least squares; pbo, placebo; PET, positron emission tomography; SE, standard error; SUVr, standardized uptake value ratio (in a composite region with pons plus vermis as a reference).