Table 1.
Clinical features of the 26 GTN patients with distant metastasis treated at Zhejiang University School of Medicine Women’s Hospital from 1999 to 2019
| Characteristics | Patients |
|---|---|
| Age (years) | |
| < 40 | 17 (65.4%) |
| ≥ 40 | 9 (34.6%) |
| Blood type | |
| A/+ | 10 (38.5%) |
| B/+ | 6 (23.1%) |
| AB/+ | 2 (7.7%) |
| O/+ | 6 (23.1%) |
| Unknown | 2 (7.7%) |
| Antecedent pregnancy | |
| Molar pregnancy | 6 (23.1%) |
| Term pregnancy | 9 (34.6%) |
| Abortion | 9 (34.6%) |
| Ectopic pregnancy | 2 (7.7%) |
| Interval (months)a | |
| ≤ 6 | 9 (34.6%) |
| 7–12 | 4 (15.4%) |
| > 12 | 13 (50.0%) |
| HCG level before treatment (IU/L) | |
| ≤ 104 | 6 (23.1%) |
| > 104–105 | 13 (50.0%) |
| > 105 | 7 (26.9%) |
| The maximum diameter (cm) (different imaging tests) | |
| < 5 | 14 (53.8%) |
| ≥ 5 | 12 (46.2%) |
| Number of tumor lesions | |
| ≤ 8 | 14 (53.8%) |
| > 8 | 12 (46.2%) |
| Metastatic sites | |
| Lung | 18 (69.2%) |
| Brain | 14 (53.8%) |
| Hepatic | 8 (30.8%) |
| Gastrointestinal | 4 (15.4%) |
| Spleen | 3 (11.5%) |
| Renal | 3 (11.5%) |
| Pancreas | 2 (7.7%) |
| Adrenal gland | 1 (3.8%) |
| Other distant sites | Gallbladder, pleura, peritoneum, abdominal wall, lymphonodus, skin, muscle, etc. |
| Lung or reproductive organs with more other organs | 21 (80.8%) |
| Only special sites | 5 (19.2%) |
| FIGO scoreb | |
| 0–6 | 1 (3.8%) |
| 7–12 | 5 (19.2%) |
| ≥ 13 | 6 (23.1%) |
| Chemoresponse | |
| Sensitive | 15 (57.7%) |
| Resistant | 6 (23.1%) |
| Dependent | 5 (19.2%) |
| Primary chemotherapy regimen is EMA-CO or EP-EMA | |
| Yes | 18 (69.2%) |
| No | 8 (30.8%) |
| Surgery | |
| Yes | 19 (73.1%) |
| No | 7 (26.9%) |
| Pathological pattern | |
| Choriocarcinoma | 9 (34.6%) |
| ETT | 4 (15.4%) |
| PSTT | 2 (7.7%) |
| Invasive mole | 3 (11.5%) |
| Coexisting | 2 (7.7%) |
| Unknown | 6 (23.1%) |
| Status | |
| No evidence of disease (NED) | 15 (57.7%) |
| Dead | 7 (26.9%) |
| Under treatment | 2 (7.7%) |
| Lost to follow up | 2 (7.7%) |
EMA-CO etoposide, methotrexate, dactinomycin-cyclophospha-mide, vincristine, EP-EMA etoposide, methotrexate, dactinomycin-etoposide, cisplatin, IU/L international units per liter; cm: centimeter
aInterval from the termination of last known pregnancy to the diagnosis of GTN
bThe FIGO prognostic scoring system was inapplicable to patients with ITT