Table 1.
Clinico-pathological data and medical histories of sCJD and vCJD cases whose tissues were tested by bioassay
| Patient | PRNP genotype codon 129 | Gender | Age at onset (years) | Disease durationa | Medical and surgical history |
|---|---|---|---|---|---|
| sCJD 1 | MM | F | 73 | 3 mo | Tonsillectomy (age 6 y), idiopathic thrombocytopenia purpura (age 31 y), splenectomy (age 33 y), thyroidectomy (age 51 y) |
| sCJD 2 | MM | F | 57 | 24 mo | Hysterectomy (age early 30 s), breast cancer lumpectomy (age 46 y), mastectomy (age 53 y), axillary node clearance (age 54 y) |
| sCJD 3 | MM | M | 67 | 1 mo | Sutures to hand (age 35 y), excision of cyst on neck (age 45 y), laser treatment to eyes (age 65 y) |
| sCJD 4 | MM | F | 65 | 4 mo | Tonsillectomy (age 20 s), caesarean section (age 35 y), cervical laminectomy and bone graft (age 48y), endometrial polyp excision (age 56 y), bilateral varicose vein surgery (age 61 y), hiatus hernia (age 65 y) |
| sCJD 5 | MM | F | 64 | 3 mo | Bilateral otosclerosis (age 39 y), osteoporosis (age 50 y), gallstones (age 58 y), wound exploration and repair of radial distal nerve + sutures (age 59 y), polypectomy at colonoscopy (age 60 y), closed fracture calcaneus (age 60 y) |
| vCJD 1 | MM | M | 25 | 10 mo | Fractured L medial malleolus (age 11 y), sutures to R thumb (age 18 y) |
| vCJD 2 | MM | M | 25 | 10 mo | Tonsillectomy (age 12 y), fractured L wrist (age 12 y), minor head injury (age 22 y) |
| vCJD 3 | MM | M | 32 | 18 mo | Nasal manipulation (age 14 y), plaque psoriasis (age 27 y) |
| vCJD 4 | MM | F | 16 | 18 mo | Adenoidectomy and insertion of L grommet (age 7 y) |
| vCJD-AS | MV | F | 82 | – | Blood transfusion after bowel resection (age 78 y), hyperthyroidism (age 30 s), kidney stones (age 43), hysterectomy (age 45 y), bowel abscess (ag e 49 y), hypothyroidism (age 57 y), chronic obstructive airways disease (age 63 y), excision basal cell carcinoma (age 71y), diverticular disease—> sigmoid resection (age 72 y), congestive cardiac failure (age 74 y), abdominal aortic aneurysm (age 74 y), spinal osteoporosis (age 74 y), acne rosacea (age 74 y), angina pectoralis (age 76 y), cataract operation × 2 (age 79 y and 82 y) |
| NC | MM | F | 80 | – | Alzheimer’s disease, cerebral infarction and ischaemia. (No other data available) |
aNumber of months (mo) after disease onset