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. 2021 Jan 22;141(3):455–466. doi: 10.1007/s00401-020-02260-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Histological and genetic characteristics of RELA-like, tanycytic, and astroblastoma-like tumors. a Haematoxylin/eosin (HE) staining of case 3 (RELA-like group). b RelA immunohistochemistry displaying no nuclear accumulation of the p65-RelA protein. c EMA positivity in some tumor cells. d genomic copy number profile of case 3 showing gains of chromosomes 17 and 19 but an otherwise balanced genome. e, f HE staining of a tanycytic ependymoma (case 14) with typical elongated cell processes highlighted in the GFAP immunohistochemistry (g). h copy number profile of this case showing copy number losses of 1p and 3p as well as chromosomes 13, 14, and 22, and chromothripsis of chromosome 16. i, j HE of case 17 illustrating the astroblastoma-like appearance, strongly highlighted in the GFAP immunohistochemistry (k). l copy number profile of case 17 showing structural alterations of chromosomes 20 and 22 (chromothripsis) (scale bars in a, e, i: 50 µm; scale bars in b, c, f, g, j, k: 20 µm)