Table 2.

Demographics, clinical information and locations of malformations between HD versus non-HD brains of the discovery cohort

Group	Case #	Age at death (years)	Sex	CAG repeat length of expanded allele	Post-mortem diagnosis	Location	Malformation type
HD	1	41	Woman	47	HD 3/4*	Atrium, left	Periventricular nodular heterotopia
	2	68	Woman	44	HD 3/4	Roof of temporal horn of lateral ventricle, left	Periventricular nodular heterotopia
	3	58	Woman	Unknown	HD 3/4	Above tail of caudate nucleus, left	Periventricular nodular heterotopia
	4	59	Woman	42	HD 3/4	Tuber cinereum	Hypothalamic hamartoma
	5	75	Woman	42	HD 2/4	Prefrontal subcortical white matter, left	Multinodular and vacuolating neuronal tumor of the cerebrum (MVNT)
	6	72	Man	40	HD 2/4	Cerebellar white matter, left	Cerebellar nodular heterotopia
	7	72	Woman	Unknown	HD 1/4	Cerebellar white matter, left	Cerebellar nodular heterotopia
	8	36	Woman	52	HD 4/4	1) Above tail of caudate nucleus, right 2) Insular cortex, right	1) Periventricular nodular heterotopia 2) Glial microhamartoma/ heterotopia
Non-HD	9	92	Woman	N/A	ADNC	Frontal subcortical white matter, left	Periventricular nodular heterotopia
	10	91	Man		ADNC	Superolateral angle of the lateral ventricle, left	Periventricular nodular heterotopia
	11	79	Woman		ADNC	Prefrontal subcortical white matter, left	Subcortical nodular heterotopia
	12	86	Man		ADNC	Roof of temporal horn	Periventricular nodular heterotopia
	13	90	Woman		ADNC	Temporal pole, subcortical white matter, left	Subcortical band heterotopia
	14	67	Woman		ADNC	Alveus, hippocampus, left	Periventricular nodular heterotopia
	15	74	Man		Control	Frontal, right	Multiple heterotopia, nodular and band
	16	66	Man		Control	Superolateral angle of lateral ventricle, right	Periventricular nodular heterotopia
	17	90	Man		ADNC	Temporal pole, subcortical white matter, left	MVNT
	18	80	Man		DLB/ PD	Optic radiation, temporal, left	Periventricular nodular heterotopia
	19	81	Man		Multi-infarct dementia	Cerebral leptomeninges	Leptomeningeal glioneuronal heterotopias, multifocal
	20	93	Woman		ADNC	Cerebellar white matter, left	Cerebellar nodular heterotopia

^*Refers to Vonsattel grade of HD [63]