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. 2021 Jan 30;141(3):399–413. doi: 10.1007/s00401-021-02269-4

Table 5.

Associations with malformation in both cohorts

Characteristic Odds ratio (95% CI) P
All participants (HD and non-HD), = 3918
HD status 5.12 (2.25–11.66) 9.9 × 10-5
Age at death 1.01 (0.98–1.03) 0.60
Sex 1.37 (0.66–2.85) 0.40
HD only, = 711
Age at death 0.99 (0.96–1.03) 0.68
Sex 4.56 (1.27–16.3) 0.020
Non-HD only, n = 3207
Age at death 1.03 (0.99–1.08) 0.17
Sex 0.44 (0.15–1.32) 0.14

Binary logistic regression with malformation as dependent variable. HD status was dichotomized as HD = 1, non-HD = 0 and sex as female = 1, male = 0.