Table 2.
CTC recovery in spiked human blood samples using Parsortix® versus CellSearch®
| Cell type | Number of cells spiked | Cells recovered (Parsortix®) | Cells recovered (CellSearch®) | P-value |
|---|---|---|---|---|
| Baseline (Pre-stained MDA-MB-468) | 5 | 4.4 ± 0.1 | 3.3 ± 1.0 | 0.4226 |
| 10 | 5.1 ± 1.5 | 8.0 ± 2.1 | 0.1994 | |
| 100 | 50.5 ± 7.8 | 70.4 ± 11.0 | 0.0989 | |
| 1000 | 604.2 ± 25.4 | 768.6 ± 64.9 | 0.1213 | |
| Epithelial (MDA-MB-468) | 5 | 2.8 ± 0.45 | 3.3 ± 1.5 | 0.6349 |
| 10 | 7.3 ± 2.4 | 5.8 ± 0.5 | 0.6968 | |
| 100 | 44.5 ± 1.6 | 63.9 ± 10.8 | 0.2236 | |
| 1000 | 547.7 ± 43.9 | 846.4 ± 83.6 | 0.0417* | |
| Mesenchymal (PC-3) | 5 | 2.9 ± 0.7 | 1.8 ± 0.4 | 0.2254 |
| 10 | 4.6 ± 0.9 | 4.2 ± 0.6 | 0.2254 | |
| 100 | 61.7 ± 8.5 | 43.9 ± 8.0 | 0.0489* | |
| 1000 | 540.6 ± 23.0 | 362.0 ± 57.2 | 0.0473* |
*Significantly different between 2 CTC analysis platforms (p ≤ 0.05)