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. 2021 Feb 1;12:558003. doi: 10.3389/fmicb.2021.558003

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Copyright © 2021 Zhong and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism diagram of quorum sensing inhibition or quenching through the QS system in A. baumannii. The QS system participates in the formation of biofilm and virulence of A. baumannii via various autoinducers, thus resulting in antimicrobial resistance. In contrast, the two main mechanisms of QS interference, quorum sensing inhibition and quorum quenching, have been developed to inhibit the virulence of bacteria, thus reducing the pressure to produce bacterial drug resistance.