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. 2021 Feb 1;12:626096. doi: 10.3389/fphys.2021.626096

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Copyright © 2021 Rovina, da Rocha, Marafon, Pauli, de Moura, Cintra, Ropelle and da Silva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The violin plot shows the Nr1d1 gene expression distribution in the muscle of 42 BXD mice strains (B) Nr1d1 gene expression in each BXD strain muscle. (C) Heatmap graph highlighting the gene expression in 4 BXD strains with low (blue) and 4 BXD strains with high (red). (D) Pearson’s correlation and (E) two factors analysis graphs show the correlation between Nr1d1gene expression and Prkaa1 mRNA levels, mitochondrial-related, and ribosomal-related genes. Blue lines indicate negative and red lines indicate a positive correlation.