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Exercise induces increase of PCG1a expression in skeletal muscle, which in turn drives the production of membrane protein fibronectin type III domain-containing protein 5 (FNDC5). The FNDC5 is cleaved and secretes irisin (blue ball). Irisin enters in the blood circulation and participates in the metabolic regulation of lipid and glucose in some organs such as skeletal muscle, liver, and adipose tissue.
