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. 2021 Feb 1;11:619740. doi: 10.3389/fphys.2020.619740

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Copyright © 2021 Sheng, Yang, Liu, Yu, Guo, Guan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ophiopogonin A alleviates renal injury in the HS rat model. (A) Representative kidney HE staining of sham + vehicle (n = 6), sham + ophiopogonin A high c (n = 6), HS + vehicle (n = 6), HS + ophiopogonin A low c (n = 6), HS + ophiopogonin A medium c (n = 6), and l HS + ophiopogonin A high c (n = 6) groups. (B) Representative kidney TUNEL staining. (C) The changes of serum creatinine and BUN in rats. (D) Relative mRNA expression of KIM-1 and NGAL in the kidney. (E) Relative protein expression of KIM-1 and NGAL in the kidney. (F) MPO-positive cells recruitment in kidney detected by immunohistochemistry. (G) The expression of iNOS in rats. (H) The amounts of TNF-α, IL-1β, and IL-6 determined by ELISA assay. Data were presented as mean ± SD. ^∗∗P < 0.01, ^#P < 0.05, ^##P < 0.01 compared with the corresponding control group.