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. 2021 Feb 1;11:619740. doi: 10.3389/fphys.2020.619740

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Copyright © 2021 Sheng, Yang, Liu, Yu, Guo, Guan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of Nrf2 reverses the functions of ophiopogonin A in vivo. (A) Relative mRNA expression of Nrf2 in sham and sham + siNrf2 group in vivo. (B) Relative protein expression of Nrf2 in sham and sham + siNrf2 group in vivo. (C) Relative mRNA expression of Nrf2 in HS, HS + ophiopogonin A, and HS + ophiopogonin A + siNrf2 group. (D) Relative mRNA expression of Nrf2. (E) Relative protein expression of Nrf2. (F) The changes in serum creatinine and BUN in rats. (G) MPO-positive cells recruitment in kidney detected by immunohistochemistry. (H) The expression of iNOS in rats. (I) The amounts of TNF-α, IL-1β, and IL-6 determined by ELISA assay. Data were presented as mean ± SD. ^∗∗P < 0.01, ^∗P < 0.05, ^#P < 0.05, ^##P < 0.01 compared with the corresponding control group.