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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: J Rheumatol. 2020 Aug 15;48(4):575–578. doi: 10.3899/jrheum.200378

Figure 1.

Figure 1

Representative skin biopsies from 10 cm above the lateral malleolus, bright-field, 40 x. Scale bar =100μm; arrows demonstrate epidermal nerve fibers

A. Healthy control: Biopsy from 17.9-year-old Caucasian female with epidermal neurite density (END) of 500/mm2 skin surface area; at the 64.3 percentile of the age, sex, and race-adjusted normal distribution.

B. Juvenile fibromyalgia patient: Biopsy from a 17.8-year-old Caucasian patient with END (242/mm2 skin surface area) at the 4.7 centile of predicted.