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. 2021 Feb 1;11:620972. doi: 10.3389/fimmu.2020.620972

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Copyright © 2021 Mielcarska, Bossowska-Nowicka and Toka

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of endosomal TLR localized in the endosome/cell membrane, exemplified by TLR3—shown are dimerization site, ECD (ectodomain/extracellular domain), transmembrane helix, and TIR domain (Toll-interleukin-1-receptor domain), as well as functions of the essential elements of the receptor (19–28).