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Scheme of TLR3 transportation in the cell. The transportation route is initiated in the ER and terminates in the lysosome—site of degradation. TLR3 present on the cell surface may recognize the dsRNA, which is a viral replication intermediate for some viruses, derived from necrotic infected cells. The dsRNA can also be endocytosed and recognized by TLR3 in the endosomes. Pathways requiring further examination are marked with dashed lines.
