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. 2021 Feb 1;11:624971. doi: 10.3389/fimmu.2020.624971

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Copyright © 2021 Koga, Ichinose, Kawakami and Tsokos

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aberrant T cell signaling and interleukin (IL)-17 production in SLE pathogenesis. SLE, systemic lupus erythematosus; TCR, T cell receptor; PP2Ac, Protein phosphatase 2A catalytic subunit; CaMK4, Calcium/calmodulin-dependent protein kinase IV; ROCK, Rho-associated protein kinase; CREB, cAMP response element binding protein; IRF4, interferon regulatory factor 4; CREM, cAMP response element modulator; mTORC1, mammalian target of rapamycin complex 1.