Table 1.

Alternatively spliced Sp100 C-terminal domains involved in chromatin regulation.

Domain	Isoform(s)	Function	Reference(s)
HMG2	Sp100B/C/HMG	DNA binding (see below).	(Lehming et al., 1998)
SAND	Sp100B/C/HMG	DNA binding to unmethylated cytosines of CpGs dinucleotides.	(Guldner et al., 1999; Bottomley et al., 2001; Wilcox et al., 2005; Isaac et al., 2006)
HMG1/2	Sp100HMG	Shapes an L composed of three α-helices that bind and open the minor groove of DNA while narrowing the major one thus, bending the DNA and allowing the assembly of nucleosome and other proteins.	(Seeler et al., 1998; Guldner et al., 1999; Thomas, 2001; Malarkey and Churchill, 2012; Newhart et al., 2013; Lohani and Rajeswari, 2016)
CC	Sp100HMG	Unknown.	ELM prediction (Kumar et al., 2020)
PHD	Sp100C	Binds with most affinity to histone 3 unmethylated in Lys4 (H3K4me0) but tri-methylated in Lys9 (H3K9me3).	(Zhang et al., 2016)
BRD	Sp100C	Unclear binding to acetylated Lys (KAc).	(Filippakopoulos and Knapp, 2012; Zhang et al., 2016)