Table 3.
Influence of early nutritional intervention on patients with head and neck radiotherapy.
| Author | Year | Patients | Treatment | Result | p | |
|---|---|---|---|---|---|---|
| ENG | CG | |||||
| Meng et al. (89) | 2019 | 46 | 32 | CRT | CT/CRT break:10.9% VS. 25.0% | 0.017 |
| days of CRT delayed for toxicity: 2.2 ± 1.8 VS. 3.1 ± 3.2 | 0.033 | |||||
| rate of patients with unplanned hospitalizations:13.0% VS. 31.3% | 0.009 | |||||
| advanced oral mucositis (3, 4):13.0% VS. 21.9% | 0.028 | |||||
| Paccagnella et al. (92) | 2010 | 33 | 33 | CRT | weight loss: −2.4 ± 8.2% VS. −9.6 ± 8.1% | 0.0077 |
| CT/CRT break:30.3% VS. 63.6% | 0.007 | |||||
| days of CRT delayed for toxicity: 4.4 ± 5.2 VS. 7.6 ± 6.5 | 0.038 | |||||
| rate of patients with unplanned hospitalizations: 16.1% VS. 41.4% | 0.030 | |||||
| Piquet et al. (96) | 2002 | 45 | 45 | RT | weight loss: 3.5 ± 0.7% VS. 6.1 ± 0.7% | <0.01 |
| hospital admission for dehydration: 0% VS. 18.0% | <0.01 | |||||
| Wang et al. (87) | 2012 | 35 | 23 | CCRT | weight loss:−1.68 ± 6.33% VS. −6.55 ± 7.28% | <0.01 |
| CT/CRT break: 28.6% VS. 73.9% | 0.010 | |||||
| albumin level change: −15.05 ± 10.41% VS. −27.38 ± 11.41% | 0.002 | |||||
| Wei et al. (86) | 2020 | 28 | 26 | CT/CRT | weight loss: −5.64 ± 2.54kg VS. −8.77 ± 1.61kg | <0.001 |
| albumin level change: −4.79 ± 3.69g/L VS. −7.09 ± 3.39g/L | <0.001 | |||||
| hemoglobin loss: −12.96 ± 19.83 g/L VS. -14.81 ± 24.47 g/L | <0.001 | |||||
| advanced oral mucositis (3, 4):17.9% VS. 50.0% | 0.012 | |||||
| Isenring et al. (99) | 2004 | 29 | 31 | RT | weight loss: −0.4kg VS. −4.7kg | <0.001 |
| NI are beneficial to global QoL | 0.009 | |||||
| González-Rodríguez et al. (97) | 2020 | 135 | 39 | RT | malnutrition: 31.9% VS. 69.5% | 0.0001 |
| emergency visits 0. 75 VS. 1.1 episodes per patient | 0.021 | |||||
| hospitalizations: 29% VS. 59% | 0.044 | |||||
| Kono et al. (88) | 2020 | 32 | 61 | CCRT | Grade III mucositis: 25.0% VS. 70.0% | 0.006 |
ENG, early nutritional intervention group; CG, control group; RT, radiotherapy; CRT, chemoradiotherapy; CCRT, concurrent chemoradiotherapy; NI, nutrition intervention; QoL, quality of life. Values of p < 0.05 were considered significant.