Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for how CMT mutations in INF2 reduce mitochondrial mobility. Normal INF2 is autoinhibited as indicated by open conformation compared to the closed conformation and thus has regulated actin-assembly activity. CMT mutations in INF2 reduce autoinhibition, resulting in excessive actin assembly on mitochondria and potentially other organelles, which in turn reduces their mobility.
