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. 2021 Feb 1;8:620793. doi: 10.3389/fmolb.2021.620793

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Copyright © 2021 Birolo, Benevenuta, Fariselli, Capriotti, Giorgio and Sanavia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Precision (y-axis) of the protein stability-based methods in predicting pathogenicity at different |ΔΔG| values, defined as the ratio of truly pathogenic over all the variants reporting predicted |ΔΔG| values above a specific threshold (x-axis). Solid and dashed lines are computed on variants in haploinsufficient and non-haploinsufficient genes, respectively. INPS3D and PoPMuSiC lines stop earlier since the methods do not provide predictions with |ΔΔG| values greater than the reported thresholds.