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. 2021 Feb 1;8:630340. doi: 10.3389/fcell.2020.630340

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Copyright © 2021 Ma, Tian, Zhong, Wu, Zhang, Liu, Dang, Chen, Zou and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epithelium of nasal polyps demonstrated a low expression of WDPCP and had decreased cilia beating frequency compared with control subjects. (A) The expression of WDPCP in the cytoplasm of epithelial cells from nasal polyps (NP) was decreased as determined by immunohistochemical staining (brown color). Scale bar: 50 μm. (B,C) Western blot images and densitometry showed decreased WDPCP protein levels in NP compared with nasal mucosa from control subjects (n = 3). (D) The copy number of WDPCP mRNA was decreased in NP (n = 3). (E) Cilia beating frequency (CBF) was significantly reduced in NP compared with control mucosa (n = 5).