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. 2021 Feb 1;10:540332. doi: 10.3389/fonc.2020.540332

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Copyright © 2021 Wu, Chen, Dong, Xu, Jian, Xu, Zhang, Wei, Yu, Wang, Wang, Liu, Sun and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ST3Gal IV downregulation was associated with the malignant degree of cervical cancer tissues. (A) IHC analysis of ST3Gal IV expression in normal cervix tissues and different grades of cervical cancer tissues. (The first and second rows: magnification, ×4, scale bars, 400 μm; the third row: magnification, ×40, scale bars, 50 μm). (B) Boxplot of IHC scores shown ST3Gal IV protein expression levels in normal cervix tissues and cervix cancer tissues, p < 0.05. (C) Pearson’s chi-squared test identified a significant correlation between ST3Gal IV expression with cancer tissue pathologic grade, p = 0.005 (normal tissue did not participate in statistics).