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. 2021 Feb 1;10:540332. doi: 10.3389/fonc.2020.540332

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Copyright © 2021 Wu, Chen, Dong, Xu, Jian, Xu, Zhang, Wei, Yu, Wang, Wang, Liu, Sun and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ST3Gal IV upregulation suppressed cervical cancer cell growth and colony formation in vitro. (A, B) The high expression of ST3Gal IV was connected with poor proliferation in HeLa and SiHa cell as shown by CCK-8 and performed in triplicate. (C, D) Cell colony formation assay adopted to further verify. (E, F) The relative cell colony formation rates of HeLa and SiHa cells from three independent experiments. (G–I) EdU proliferation assay revealed ST3Gal IV overexpression inhibited the DNA synthesis ability of HeLa and SiHa cells and data are from three independent experiments. (Magnification, ×20, scale bars, 100 μm). All values represent the mean ± SD (* p < 0.05).