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. 2021 Feb 1;11:600227. doi: 10.3389/fgene.2020.600227

TABLE 1.

Univariate and multivariate analysis of variables of OS in non-M3 AML patients.

Variables
Univariate analysis
Multivariate analysis
HR(95%CI) P HR(95%CI) P
CDK6 expression 1.000(1.000-1.000) 0.047 1.000(1.000-1.000) 0.069
Age 1.033(1.019-1.048) 0 1.018(1.000-1.036) 0.045
BM_Blast_Percentage 1.004(0.994-1.014) 0.46 1.013(1.001-1.026) 0.039
WBC 1.003(0.999-1.007) 0.191 1.002(0.997-1.008) 0.411
PB Blast_Percentage 0.998(0.992-1.005) 0.617 1.005(0.996-1.014) 0.265
Risk cytogenetic-poor 1.859(1.229-2.813) 0.003 2.444(1.417-4.215) 0.001
Treatment transplant 0.414(0.281-0.611) 0 0.367(0.223-0.604) 0
WT1 0.871(0.404-1.875) 0.723 1.14(0.490-2.650) 0.761
TP53 3.167(1.817-5.520) 0 2.761(1.314-5.798) 0.007
FLT3 1.234(0.811-1.876) 0.326 1.258(0.727-2.176) 0.411
TET2 0.896(0.468-1.718) 0.742 0.691(0.341-1.400) 0.305
RUNX1 1.472(0.821-2.638) 0.194 3.290(1.619-6.686) 0.001
IDH2 0.929(0.509-1.697) 0.811 0.521(0.261-1.040) 0.065
IDH1 0.629(0.318-1.246) 0.184 0.497(0.215-1.144) 0.1
NRAS 0.810(0.376-1.745) 0.591 0.632(0.274-1.456) 0.281
NPM1 1.014(0.674-1.526) 0.946 0.872(0.471-1.616) 0.664
KRAS 1.528(0.670-3.482) 0.314 1.876(0.710-4.955) 0.205
DNMT3A 1.393(0.923-2.102) 0.114 1.874(1.145-3.067) 0.012
CEBPA 0.833(0.421-1.648) 0.599 2.504(1.134-5.528) 0.023