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. 2021 Feb 1;11:591515. doi: 10.3389/fgene.2020.591515

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Copyright © 2021 Yao, Ding, Bai, Zhou, Lee, Li and Teng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of 16 candidate serum miRNA signatures and their characterization in the discovery datasets. (A) Venn diagram showing significant differentially expressed (DE) miRNAs in the discovery dataset GSE113458 and GSE124158. The 16 miRNAs are listed in the table on the right along with the adjusted p-value and fold change. (B) Box plots showing higher expression levels of the 16 identified miRNAs in gastric cancer patients compared with the non-cancer control patients in GSE113486 and GSE124158. (C) Heatmap showing a promising result of the hierarchical clustering analysis using the 16 identified miRNAs to distinguish different samples in GSE113486 and GSE124158. NC, non-cancer control patients.