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. 2021 Feb 10;12:2041731420981339. doi: 10.1177/2041731420981339

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Modeling muscular dystrophies using tissue engineering. (a) 3D artificial skeletal muscle constructs derived from healthy and dystrophic hPSCs. Immunofluorescence for myosin heavy chain (MyHC) on muscle constructs derived from hESCs and dystrophic hiPSCs (DMD, LGMD2D, and skeletal muscle LMNA) differentiated in 3D for 10 days. Nuclei are counterstained with Hoechst. Arrowheads: multinucleated myotubes. Scale bars: top 250 μm, bottom 25 μm. (b) Confocal (z stacks merge) immunofluorescence for DESMIN (myotubes), LAMIN A/C, and EMERIN (nuclear lamina) on hiPSC-derived (healthy and LMNA mutant) artificial muscles. Hoechst: nuclei. Scale bars: 15 μm. Adapted from Maffioletti et al.⁹².