Fig. 1.

Schematic diagram of SARS-CoV-2 infection cycle. S protein priming facilitates the binding of the virus with angiotensin converting enzyme—2 (ACE2) and thereby fusion of viral and cellular membrane occurs. This, in turn, releases a viral genome inside the cell. The next step is translation of the viral replicase gene followed by RNA replication to produce genomic RNA and subgenomic RNAs. Subgenomic RNAs are then translated into proteins, and genomic RNA is packaged with N proteins and along with all other structural proteins (i.e., N, E, S, M). The assembly of the virus occurs in various steps by Endoplasmic Reticulum and Golgi network. Mature virion inside the vesicle then released from the cell