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. 2021 Feb 15;33(8):2123–2132. doi: 10.1007/s40520-021-01793-3

Fig. 1.

Fig. 1

Prisma 2009 flow diagram. The flowchart illustrates the search strategy applied to answer the research question outlined. In total 479 studies were identified during the systematic data search (468 in scientific literature, 11 additional publications by hands-on search). Following qualitative evaluation and screening full text, 44 studies fulfilled predefined inclusion criteria of the publication and were further analysed in the review process