Table III.
Association between SQLE expression and clinicopathological parameters of patients with breast cancer (n=198).
| Characteristics | High SQLE expression, n/total n (%) | P-valuea |
|---|---|---|
| Age, years | >0.05 | |
| ≤46 | 40/112 (35.7) | |
| >46 | 41/86 (47.7) | |
| Histopathologic type | >0.05 | |
| Invasive ductal carcinoma, NOS | 67/171 (39.2) | |
| Invasive lobular carcinoma | 14/25 (56.0) | |
| Mucinous carcinoma | 0/2 (0.0) | |
| Tumor size, cm | <0.05 | |
| ≤2 | 11/35 (31.4) | |
| 2–5 | 51/133(38.3) | |
| >5 | 19/30 (63.3) | |
| Number of nodal metastasis | <0.001 | |
| 0 | 29/105 (27.6) | |
| 1–3 | 25/51 (49.0) | |
| 4–9 | 13/25 (52.0) | |
| ≥10 | 14/17 (82.4) | |
| Histological grade | >0.05 | |
| 1 | 4/26 (15.4) | |
| 2 | 47/101 (46.5) | |
| 3 | 30/71 (42.3) | |
| Stage | <0.01 | |
| I | 11/35 (31.4) | |
| II | 37/112 (33.0) | |
| III | 33/51 (64.7) | |
| Estrogen receptor-α | >0.05 | |
| Negative | 40/87 (46.0) | |
| Positive | 41/111 (36.9) | |
| Progesterone receptor | >0.05 | |
| Negative | 39/87 (44.8) | |
| Positive | 42/111 (37.8) | |
| HER2 | >0.05 | |
| Negative | 64/162 (39.5) | |
| Positive | 17/36 (47.2) | |
| Molecular subtypes | <0.05 | |
| Luminal | 50/135 (37.0) | |
| HER2 | 14/21 (66.7) | |
| Triple negative | 17/42 (40.5) | |
| Distant metastatic relapse | <0.05 | |
| No | 52/146 (35.6) | |
| Yes | 29/52 (55.8) |
a
Analyzed by χ2 test. NOS, not otherwise specified; SQLE, squalene epoxidase.