Figure 5.

Siomycin A diminished Ang II‐induced β‐catenin activation and profibrotic responses in NRK‐52E. Cells were pre‐treated with Siomycin A (0, 0.1, 0.5, 1 μM) for 0.5 h and then treated with Ang II (10⁻⁶ M) for 48 h. A, C and E, Representative Western blot, B, quantitative data for FoxM1, D, quantitative data for Wnt1, Wnt2b, Wnt3 and F, quantitative data for active β‐catenin, Snail, E‐cadherin, fibronectin, Col I and α‐SMA (n = 3). *P < .05, **P < .01 vs Con. ^# P < .05, ^## P < .01 vs Ang II. Con, control; Col I, collagen I; α‐SMA, α‐smooth muscle actin