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. 2020 Dec 30;25(4):2228–2237. doi: 10.1111/jcmm.16215

FIGURE 2.

FIGURE 2

Huaier inhibits A549 glucose metabolism. Huaier (2, 4 and 8 mg/mL) was used to treat lung cancer A549 cells for 24 h. (A), Huaier markedly decreased the glucose consumption in a dose‐dependent manner; (B) Huaier distinctly diminished the LA accumulation; (C‐E) Huaier conspicuously lessened the key enzymes for glucose metabolism in both mRNA and protein levels. HK‐II, Hexokinase II; PFK, phosphofructokinase; PK, pyruvate kinase; GLUT1, glucose transporter 1; LA, lactic acid. Compared with control group, *P < .05 or **P < .01; #compared with 4 mg/mL group, P < .05