FIGURE 1.

LncRNA ADAMTS9‐AS2 is down‐regulated during OSF carcinogenesis and associated with poor prognosis in OSCC patients. A, Heat map of ADAMTS9‐AS2 family members differentially expressed in normal mucous, OSF and OSCC samples. B, ADAMTS9‐AS2 RNA levels were quantified by qRT‐PCR in normal mucous, OSF and OSCC cells. **P < .01; ***P < .0001. C, qRT‐PCR analysis of ADAMTS9‐AS2 in tissue samples from normal mucous (n = 5), OSF (n = 10) and OSCC (n = 19) samples. ADAMTS9‐AS2 expression was normalized to GAPDH (‐ΔCt). Data were presented as 2^‐ΔΔCt. *P < .05; ***P < .0001. D, Kaplan‐Meier curves for overall survival of OSCC patients with low vs high expression of ADAMTS9‐AS2