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. 2020 Dec 30;25(4):1972–1981. doi: 10.1111/jcmm.15994

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© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Complex 1 suppressed tumour growth in a A375 xenograft model in vivo and was well tolerated over the duration of treatment. (A) Effect of complex 1 on tumour size. (B) Representative photograph images of tumours in treatment and control groups. (C) Effect of complex 1 on tumour weight. (D) Effect of complex 1 on mouse total body weight. (E) Survival curves of mice in treatment and control groups. (F) Effect of complex 1 on p21, Bax, MEK, ERK, p‐MEK and p‐ERK protein levels in tumour tissues after sacrifice. (G) The protein band density in panel F was analysed. Error bars represent standard deviation of the means of the results from three independent experiments