TABLE 1.
Intake levels during and blood levels after the last FR2 session in rats self-administering nicotine and cotinine at various doses
Because of poor resolution during high performance liquid chromatography analysis, one nicotine value was missing from one rat in the 0.03NIC group.
| Drug | Milligrams per Kilogram per Infusion | Intake (n) | COT (n) | NIC (n) |
|---|---|---|---|---|
| mg/kg | ng/ml | ng/ml | ||
| COT | 0.0075 | 0.13 ± 0.01 (13) | 77 ± 10 (13) | — |
| 0.015 | 0.31 ± 0.05 (10) | 199 ± 26 (10) | — | |
| 0.03 | 0.66 ± 0.14 (9)a | 449 ± 185 (9)b | — | |
| 0.06 | 1.54 ± 0.37 (12)c | 792 ± 172 (12)a | — | |
| NIC | 0.0075 | 0.42 ± 0.06 (10) | 96 ± 11 (10) | 10 ± 6 (10) |
| 0.015 | 0.54 ± 0.06 (9) | 137 ± 18 (9) | 17 ± 5 (9) | |
| 0.03 | 0.98 ± 0.13 (8)b | 228 ± 46 (8)b | 24 ± 10 (7) | |
| 0.06 | 1.88 ± 0.12 (14)c | 431 ± 54 (14)c | 46 ± 10 (14)a |
a
Significantly greater than 0.0075 and 0.015 groups.
b
Significantly greater than the 0.0075 group.
c
Significantly greater than all other groups.