TABLE 1.
Peptides designed based on the ACE2 PD a1 helix 1. A staple scan was conducted on the back face of the helix, ranging from N‐terminal stapling positions to C‐terminal stapling
| Name | Sequence |
|---|---|
| Native (1) | IEEQAKTFLDKFNHEAEDLFYQS |
| 2 | IR8EQAKTFS5DKFNHEAEDLFYQS |
| 3 | IEEQR8KTFLDKS5NHEAEDLFYQS |
| 4 | IEEQAR8TFLDKFS5HEAEDLFYQS |
| 5 | IEEQAKTFR8DKFNHES5EDLFYQS |
| 6 | IEEQAKTFLDKR8NHEAEDS5FYQS |
| 7 | IEEQAKTFLDKFR8HEAEDLS5YQS |
| 8 | IEEQAKTFLDKFNHER8EDLFYQS5 |
| 9 | HEAEDLFYQS |
| 10 | HES5EDLS5YQS |
| 11 | IEEQAKTFLDKFNHE |
| 12 | IEEQR8KTFLDKS5NHE |
| 13 | TFLDKFNHEAEDL |
| 14 | TFR8DKFNHES5EDL |
| 15 | TS5LDKS5NHEAEDL |
| Scrambled negative control | FHTSEYDEQNEIEAAQLFKDFLK |
| Stapled negative control | IEEQAKR8FLDKFNS5EAEDLFYQS |