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. 2021 Jan 6;1(3):2000049. doi: 10.1002/anbr.202000049

Figure 4.

Figure 4

Strategies for the delivery of ASOs to bacteria. a) ASOs against the gene ftsZ, critical for replication of MRSA, (panel i) are synthesized from biostable PNA and hybridized on one edge of a DNA‐based tetrahedron nanostructure. (panel ii) Their application to MRSA cells in solution inhibits growth. Reproduced with permission.[ 100 ] Copyright 2018, American Chemical Society. b) A PNA–ASO against three genes responsible for biofilm formation are (panel i) incorporated into a DNA tetrahedron, (panel ii) leading to a decrease of mature biofilm formation, as detected by crystal violet staining and optical density (OD) measurements. Reproduced with permission.[ 102 ] Copyright 2020, Springer Nature.