Table 2.

Distribution of 60 human tissue samples, selected from the data of RNA expression (https://biogps.org/),^{[ 31} , ^{32 ]} according to two instances of EM clustering, presented as two pairs of clusters of high and low RNA expression for tested RAS and related genes

Distribution of 60 tissue samples based on two EM clustering		“Perfusion” EM clusters from Table 1 and Figure 2, based on: Renin, ReninBP, ProreninRec, ACE, AT2R, ACE2, MAS1, ET‐1, ET‐1 RecA, ET‐1 RecB, TSP1
		High expression	Low expression	Total number of tissue samples
“Constriction” EM clusters from Table 1 and Figure 1, based on: ProreninRec. ACE, AT1R	High expression	High expression of both clusterings (4 samples): Liver.2 Prostate.1 CardiacMyocytes.1 CardiacMyocytes.2	High expression of the “constriction” clustering (14 samples): Adipocyte.1 Adipocyte.2 AdrenalCortex.1 Adrenalgland.1 Adrenalgland.2 Appendix.2 Bonemarrow.2 CD105+_Endothelial.2 Pancreas.1 PancreaticIslet.2 Salivarygland.1 Tongue.1 Tongue.2 Tonsil.1	18
	Low expression	High expression of the “perfusion” clustering (17 samples): Appendix.1 Liver.1 PancreaticIslet.1 SkeletalMuscle.2 Thyroid.2 Uterus.1 Uterus.2 Heart.1 Kidney.1 Kidney.2 Lung.1 Lung.2 SkeletalMuscle.1 Small_intestine.1 Small_intestine.2 SmoothMuscle.1 SmoothMuscle.2	Low expression of both clusterings (25 samples): AdrenalCortex.2 AtrioventricularNode.1 AtrioventricularNode.2 BDCA4+_DentriticCells.1 BDCA4+_DentriticCells.2 Bonemarrow.1 BronchialEpithelialCells.1 BronchialEpithelialCells.2 CD105+_Endothelial.1 Colon.1 Colon.2 Heart.2 Pancreas.2 Prostate.2 Salivarygland.2 Skin.1 Skin.2 Thymus.1 Thymus.2 Thyroid.1 Tonsil.2 Trachea.1 Trachea.2 Wholebrain.1 Wholebrain.2	42
Total number of tissue samples		21	39	60

Coronavirus infections targeting ACE2 molecules can then be particularly damaging in tissues that showed high expression of “perfusion” clustering genes in both tested samples (shown in gray cells): liver; cardiac myocytes; skeletal muscle; uterus; kidney; lung; small intestine and smooth muscle.