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. 2021 Feb 5;38(3):e14509. doi: 10.1111/dme.14509

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© 2020 Diabetes UK

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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ACE2 and its role in the renin angiotensin system and SARS‐CoV‐2 infection. ACE2 is located on cell membranes and mediates entry of SARS‐COV‐2 through binding to spike glycoproteins resulting in endocytosis. This leads to downregulation of ACE2, which is required for cleaving of angiotensin II into angiotensin‐(1‐7) which exerts anti‐inflammatory vasoprotective effects. Angiotensin converting enzyme (ACE), angiotensin converting enzyme inhibitor (ACEi), angiotensin converting enzyme 2 (ACE2), AT1 angiotensin II receptor type 1 (AT1), Mas receptor (MasR)