Table 1.

Demographics of healthy controls, fibrotic and cirrhotic patients.

	Healthy controls n=25	Fibrosis n=14	Cirrhosis n=56
Age, years	44.9±2.7	59.8±3.9	56.2±1.4
Gender (%)
Male (%)	11 (44)	8 (57)	29 (52)
Female (%)	14 (56)	6 (43)	27 (48)
Aetiology (%)
AIH		8 (57)	5 (9)
A1AT			1 (1.8)
AIH/A1AT			1 (1.8)
ArLD/A1AT			1 (1.8)
ArLD			19 (34)
HBV			2 (3.5)
HCV		1 (7)	9 (16)
HBV/HAFLD			1 (1.8)
HCV/ArLD			3 (5.4)
PBC		1 (7)	1 (1.8)
PBC/AIH		1 (7)	4 (7)
PSC		2 (14)
NAFLD		1 (7)	5 (9)
NAFLD/ArLD			2 (3.5)
Sarcoid			2 (3.5)
Blood Markers
Bilirubin (μmol/l)		11.29±5.9	50.79±19.0***
Albumin (g/l)		40.07±3.0	34.07±2.3***
Sodium (mmol/l)		139.79±2.0	138.29±0.8**
Creatinine (μmol/l)		71.29±12.3	68.14±5.6
Platelet count (10*9/l)		218.64±51.0	114.71±12.7***
Prothrombin time (sec)		11.94±0.9	14.60±0.6***
Severity Scores
INR, score (%)		0.9 (7)	1 (21.4)
		1 (43)	1.1 (14.3)
		1.1 (50)	1.2 (8.9)
			1.3 (12.5)
			1.4 (12.5)
			1.5 (10.7)
			1.6 (7.1)
			1.7 (3.6)
			2 (5.4)
			2.2 (1.8)
			2.7 (1.8)
Ascites, score (%)			1 (58.9)
			2 (14.3)
			3 (26.8)
HE, score (%)			0 (82)
			2 (9)
			3 (9)

Data are mean±SEM. **P<0.001, *** P<0.0001 cirrhotic values significantly different from fibrosis. A1AT - alpha 1 anti-trypsin, AIH - autoimmune hepatitis, ArLD - alcohol-related liver disease, HBV - hepatitis B virus, HCV - hepatitis C virus, INR - international normalised ratio, NAFLD - non-alcoholic liver disease, PBC - primary biliary cholangitis, PSC - primary sclerosing cholangitis. The Child-Pugh Score for ascites; 1 = absence of ascites, 2 = ascites mild or supressed with medication, 3 = ascites moderate to severe (or refractory). Hepatic encephalopathy (HE) was scored using West Haven criteria; 0 = absence of HE symptoms, 1 = changes in behaviour with minimal change in level of consciousness, 2 = disorientation, drowsiness, inappropriate behaviour, 3 = marked confusion, incoherent speech, sleeping but rousable to vocal stimuli.