Skip to main content
. 2021 Feb 1;12:620934. doi: 10.3389/fphar.2021.620934

FIGURE 1.

FIGURE 1

Crizotinib and sunitinib exposure induced hepatotoxicity in vitro and in vivo. (A) Cytotoxicity of crizotinib or sunitinib alone at various concentration for 48 h in L02 cells (n = 3). (B) ALT, AST and LDH levels in the supernatant following crizotinib or sunitinib exposured at different concentrations for 48 h (n = 3). (C) Serum ALT, AST and LDH levels of male C57 were determined to evaluate crizotinib- and sunitinib-caused hepatotoxicity (n = 5–7). (D) Photomicrographs (20×) of hematoxylin & eosin-stained liver sections obtained from the control, crizotinib and sunitinib groups. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. control group.