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. 2021 Feb 1;12:620934. doi: 10.3389/fphar.2021.620934

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Copyright © 2021 Guo, Gong, Tang, Zhang, Zhang and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NAC treatment decreased hepatocyte damage and restored mitochondrial apoptosis in L02 cells (n = 3). (A) L02 cells were incubated with crizotinib or sunitinib for 48 h in the presence or absence of 5 mM NAC pretreatment for 1 h. Cell viability was assessed using a MTT assay. (B) Levels of ALT, AST and LDH released into the supernatant. (C) Fold change in ROS level. (D) The altered levels of MMP were measured by JC-1 staining. (E, F) The levels of apoptosis signaling proteins were analyzed by western blotting. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. control group; ^# p < 0.05, ^## p < 0.01 and ^### p < 0.001 vs. crizotinib or sunitinib group.