Figure 5. A model for PIDDosome activation in cells with extra centrosomes.

Cycling cells normally contain a single mature parent centriole that is decorated with distal appendages. PIDD1 is recruited by ANKRD26 to the centriole distal appendage. In the presence of extra mature parent centrioles, PIDD1 is activated at the distal appendage and released into the cytoplasm to promote PIDDosome assembly and caspase‐2 activation. Active caspase‐2 cleaves MDM2 leading to stabilization of P53 and subsequent cell cycle arrest or cell death.