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. 2020 Dec 22;40(4):e104729. doi: 10.15252/embj.2020104729

Figure 4. hnRNPLL‐deficient mice are developmental impaired and growth retarded.

Figure 4

  1. Schematic of hnRNPLL knockout mouse, in which its exon two is deleted.
  2. Birth rate of the different hnRNPLL genotypes, the birth rate of hnRNPLL −/− mice was significantly lower than that of WT hnRNPLL +/+ mice. The data represent the means ± SD. t‐Test was used to determine the significance.
  3. Representative images of hnRNPLL +/+ and hnRNPLL −/− littermates at 3 weeks.
  4. Body weight growth curve of mice at different postnatal days. The data represent the means ± SD (n = 5–10). ***P < 0.001. t‐Test was used to determine the significance.
  5. Survival curve analysis for hnRNPLL +/+, hnRNPLL +/−, and hnRNPLL −/−mice (ten mice in hnRNPLL +/+/+/− group and seven mice in hnRNPLL −/−group).
  6. Genotypes and representative images of hnRNPLL +/+ embryo and retarded hnRNPLL −/− embryos at E11.5 which generated from hnRNPLL +/− intercrosses. Scale bar, 1 mm.