TABLE 3.
Analysis results for sex difference in main term and interaction term with sex and disease duration in replication cohort (reference: male)
| PD |
Control |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interaction term |
Main term |
Main term |
||||||||||
| Outcome | Beta | SE | P | Consistency with LT analysis | Beta | SE | P | Consistency with LT analysis | Beta | SE | P | Test of Homogeneity in main effect |
| UPDRS2 total | −0.185 | 0.033 | 3.2E-08 | Consistent | −0.487 | 0.184 | 8.1E-03 | Consistent | ||||
| Cognitive IADL (PDAQ-15) | 0.219 | 0.049 | 6.8E-06 | Consistent | −0.024 | 0.266 | 0.928 | Consistent | −0.668 | 0.297 | 0.025 | 0.106 |
| Dyskinesia | 0.073 | 0.032 | 0.024 | Consistent | −0.311 | 0.205 | 0.129 | |||||
| Wearing off | −0.001 | 0.041 | 0.977 | Consistent | 0.259 | 0.217 | 0.232 | Consistent | ||||
| Depression (GDS total > 5) | −0.013 | 0.010 | 0.203 | Consistent | −0.030 | 0.056 | 0.596 | Consistent | −0.165 | 0.066 | 0.012 | 0.120 |
| pRBD (single question) | −0.003 | 0.011 | 0.767 | Consistent | −0.698 | 0.059 | 1.2E-32 | −0.696 | 0.080 | 4.6E-18 | 0.990 | |
| NMSQ_Awake | 0.001 | 0.012 | 0.963 | Consistent | −0.216 | 0.072 | 2.5E-03 | −0.292 | 0.091 | 1.3E-03 | 0.514 | |
| NMSQ_Sleep | −0.003 | 0.011 | 0.789 | Consistent | 0.406 | 0.058 | 2.4E-12 | 0.492 | 0.064 | 1.4E-14 | 0.317 | |
| NMSQ_Feel | −0.004 | 0.010 | 0.676 | Consistent | 0.384 | 0.055 | 4.3E-12 | 0.342 | 0.065 | 1.6E-07 | 0.628 | |
| NMSQ_Constipation | −0.018 | 0.010 | 0.072 | Consistent | 0.173 | 0.055 | 1.7E-03 | 0.310 | 0.075 | 3.8E-05 | 0.143 | |
| NMSQ_Smell | −0.011 | 0.011 | 0.314 | Consistent | 0.034 | 0.059 | 0.568 | Consistent | −0.326 | 0.111 | 3.3E-03 | 4.2E-03 |
“Main term” is the average difference between the women and the men (reference: males). “Interaction term” is the interaction between disease duration and sex. The adjusted covariates were linear and square age for non-PD participants. For PD participants, linear and square disease duration, and indicators of levodopa and dopamine agonist usage were further adjusted.
SE, standard error; PDAQ-15, the Penn Parkinson’s Daily Activities Questionnaire-15 (15-item measure of cognitive instrumental activities of daily living (IADL) for Parkinson’s disease patients derived from the original 50-item PDAQ), ranging 0–60 (the lower the worse); Depression, Geriatric Depression Scale score more than 5. Consistency with longitudinal dataset analyses was evaluated for outcomes (Consistency with LT analysis).
Abbreviations: NMSQ, Non Motor Symptom Questionnaire; NMSQ_awake: difficult to stay awake; NMSQ_Sleep, difficulty getting sleep at night; NMSQ_Feel, feeling sad, “low” or “blue”; NMSQ_Smell, loss or change in your ability to taste or smell.